Phosphorylation sites in the cerebral cavernous malformations complex

Phosphorylation sites in the cerebral cavernous malformations complex.

Phosphorylation sites in the cerebral cavernous malformations complex Jaehong Kim1,3, Nicholas E. Sherman2, Jay W. Fox2 and Mark H. Ginsberg1,* 1Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0726, USA 2Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA 3Division of Translational Research, National Medical Center...

Cerebral cavernous malformations.

The cerebral cavernous malformations proteins.

Inherited mutations in three genes lead to the familial form of Cerebral Cavernous Malformations (CCM). These vascular dysplasias most commonly occur in the brain, and manifest as dilated, mulberry-shaped lesions with a single endothelial layer. The consequences of these lesions can be leakage and sequelae such as focal neurological deficits, epilepsy, or hemorrhagic stroke. Until recently, how...

Clinical reasoning: cerebral cavernous malformations.

Lama M. Chahine, MD Michel J. Berg, MD SECTION 1 A 40-year-old man presented for management of seizures. His first seizure was 5 years earlier. Evaluation at that time revealed a hemorrhagic lesion near the occipital horn of the left lateral ventricle. Incomplete surgical excision was performed with indeterminate pathology suggestive of an astrocytoma. MRI demonstrated 7 separate lesions consis...

The natural history of cerebral cavernous malformations.

To determine the natural history of brain cavernous malformations, the authors entered patients referred to their center into a prospective registry between 1987 and 1993. All patients underwent magnetic resonance imaging, which showed the typical appearance of this lesion, and conservative management was recommended in all. Patients or their referring physicians were contacted for follow-up da...